Regenerative INJECTION THERAPies

Targeted Injections for Pain Relief, Tissue Repair & Faster Recovery

A Targeted, Regenerative Approach to Pain Relief & Tissue Repair

Injection Therapy is a highly effective, minimally invasive approach that accelerates healing, reduces pain, restores mobility, and enhances tissue repair. At Denver Sports & Holistic Medicine, we combine Eastern medicine principles with Western sports medicine, regenerative therapies, and functional diagnostics to deliver precise, targeted results.

These treatments are ideal for patients who want faster recovery, reduced inflammation, improved circulation, and long-term structural healing—especially when progress has plateaued with massage, chiropractic care, or physical therapy alone.

What Regenerative Injection Therapy Treats

Regenerative Injection Therapy supports a wide range of musculoskeletal and pain conditions, especially when progress has plateaued with massage, physical therapy, or chiropractic care. Common conditions include:

• Muscle tightness and spasms
• Tendonitis (Achilles, elbow, shoulder, etc.)
• Myofascial pain and trigger points
• Chronic neck or low back pain
• Sciatic pain and nerve irritation
• Joint instability
• Sports-related strains and sprains
• Overuse injuries
• Scar tissue and adhesions
• Postural stress injuries
• Headaches and migraines

Injection Therapy is often combined with acupuncture, cupping, corrective exercise, and sports medicine interventions for comprehensive healing.

Types of Regenerative Injection Therapies

Trigger Point Injections (TPI)

Trigger points are tight, hyper-irritable muscle knots that limit movement and refer pain. Trigger Point Injections use a fine needle and a natural solution to:

• Release muscle contraction
• Improve circulation
• Reduce nerve irritation
• Increase range of motion
• Break chronic pain cycles

TPIs are highly effective for whiplash, tension headaches, back pain, shoulder tightness, piriformis syndrome, and postural strain.

Prolotherapy-Style Ligament & Tendon Support

Prolotherapy-style injections stimulate natural tissue repair—strengthening ligaments, stabilizing joints, and improving tendon resilience.

Benefits include:

• Improved joint stability
• Strengthening of overstretched ligaments
• Collagen regeneration
• Reduced chronic inflammation
• Increased mobility and long-term function
• Prevention of recurrent injury

Commonly treated conditions:

• Chronic low back pain
• SI joint instability
• Knee or hip instability
• Shoulder injuries and rotator cuff support
• Ankle instability
• Tendon and ligament sprains
• Athlete overuse injuries

This is an excellent option for patients seeking non-surgical regenerative healing.

Ozone Injection Therapy (Prolozone-Style Oxygen Support)

Ozone injections combine nutrients with medical ozone to improve oxygenation, stimulate mitochondrial activity, and enhance cellular repair.

Benefits include:

• Increased oxygen delivery
• Reduced inflammation
• Activation of mitochondrial function
• Improved circulation and lymphatic flow
• Stimulation of cartilage and connective tissue repair
• Faster recovery after injury or surgery

Common uses:

• Arthritis and degenerative joint pain
• Tendon and ligament injuries
• Chronic muscular tightness or pain
• Scar tissue adhesions
• Nerve irritation
• Post-surgical recovery
• Chronic inflammatory conditions

Ozone pairs synergistically with:

→ Bioenergetic & Nervous System Therapies
→ Red Light & Photobiomodulation
→ Functional & Integrative Medicine
→ Sports Medicine & Injury Recovery

Vitamin & Nutrient Injection Therapy

Nutrient injections rapidly replenish key vitamins, minerals, and cofactors essential for:

• Energy production and mitochondrial health
• Nervous system stability
• Detoxification pathways
• Muscle recovery
• Immune function
• Hormonal balance
• Mood and stress regulation

This is especially beneficial for patients with fatigue, chronic illness, mold toxicity, post-viral symptoms, or nutrient depletion.

Related services:

→ Functional & Integrative Medicine
→ Detoxification & Environmental Medicine
→ Longevity & Mitochondrial Health

Why Regenerative Injections Work So Well

Regenerative injections deliver therapeutic agents directly into the targeted tissue, allowing for:

• Immediate, local therapeutic action
• Faster pain relief
• Improved absorption and tissue penetration
• Release of dense scar tissue and adhesions
• Increased mobility and flexibility
• Deeper muscular and fascial release than manual therapy alone

Many patients experience noticeable improvement the same day, with cumulative benefits across a short treatment series.

A Comprehensive, Integrative Approach to Healing

Regenerative Injection Therapy is most effective when integrated with complementary treatments that support structural alignment, tissue repair, and whole-body physiology. Depending on your needs, injections may be paired with:

→ Acupuncture & Nervous System Regulation
→ Red Light Therapy & Photobiomodulation
→ Advanced Functional Lab Testing
→ Sports Medicine & Injury Recovery

This multi-modal approach enhances circulation, restores muscular balance, supports inflammation regulation, and promotes long-term tissue repair.

What to Expect During Treatment

• Treatments last 10–20 minutes
• Fine needles minimize discomfort
• Little to no downtime
• Improved mobility often occurs the same day
• Relief builds across a series of sessions
• Treatment plans are customized based on severity and chronicity

Who Is a Candidate for Regenerative Injection Therapy?

This therapy may be appropriate for:

• Athletes and active individuals
• Patients with chronic or recurrent pain
• Individuals not improving with PT, chiropractic, or massage
• Those with persistent muscle knots or fascial tightness
• People seeking non-pharmaceutical pain relief
• Patients recovering from surgery or injury

A detailed evaluation identifies which injection therapies—and which combination of integrative modalities—are best suited to your condition.

Ready for Faster, More Complete Healing?

Regenerative Injection Therapy offers targeted, effective support for pain relief, structural repair, and functional recovery—especially when paired with integrative, root-cause treatment.

Frequently Asked Questions about Injection Therapy

1. Do injections hurt?

Most patients describe only mild pressure or brief discomfort. We use fine needles and gentle technique, and treatments are typically well tolerated—even in sensitive areas.

2. How many injection therapy treatments will I need?

Acute issues may respond within 1–3 sessions, while chronic or long-standing conditions often require a series of treatments for lasting results. Your plan is individualized based on severity, chronicity, and goals.

3. Can injection therapy be combined with acupuncture or cupping?

Yes. Injection therapy pairs extremely well with acupuncture, cupping, gua sha, corrective exercise, and functional medicine. Combining therapies often produces faster, more complete healing.

4. Are these injections safe?

Yes. We use natural, non-steroidal solutions chosen for your individual needs. Side effects are minimal and may include temporary soreness or mild bruising at the injection site.

5. What is the difference between trigger point injections and acupuncture?

Acupuncture uses fine needles to stimulate neuromuscular and energetic pathways. Trigger Point Injections deliver a small amount of solution directly into a tight muscle knot, allowing a deeper mechanical and chemical release of chronic tension and pain.

6. Can injection therapy help nerve pain or sciatica?

Yes. Trigger Point and regenerative injections can reduce muscle spasm, decrease tissue compression on nerves, and improve biomechanics—often easing sciatica, piriformis syndrome, and cervical nerve irritation.

7. Is injection therapy helpful for athletes and active individuals?

Absolutely. These therapies accelerate recovery, reduce inflammation, improve biomechanics, and support tendon and ligament healing—helping athletes return to training safely and quickly.

8. What is prolotherapy and how does it work?

Prolotherapy is a regenerative injection technique designed to strengthen ligaments and tendons. By stimulating the body’s repair mechanisms, it promotes collagen regeneration, improves stability, and reduces chronic pain related to lax or overstretched connective tissue.

9. What conditions are best suited for prolotherapy?

Prolotherapy-style support is ideal for:

• SI joint instability
• Chronic low back pain
• Shoulder and rotator cuff support
• Knee or ankle instability
• Tendon and ligament sprains
• Overuse injuries in athletes
• Degenerative joint pain associated with instability

It is especially helpful when pain repeatedly returns due to underlying instability.

10. What is ozone injection therapy, and how is it different from prolotherapy?

Ozone injection therapy uses medical ozone to increase oxygenation, reduce inflammation, and stimulate mitochondrial repair in injured or painful tissues. Prolotherapy strengthens ligaments and tendons, while ozone therapy enhances oxygen delivery and cellular metabolism. Together, they are especially effective for arthritic joints, chronic inflammatory pain, and slow-healing tissues.

11. Is ozone injection therapy safe?

Yes. When administered properly, ozone injection therapy has a strong safety profile. Most patients tolerate it very well. Temporary soreness, pressure, or a sense of fullness at the injection site is common as circulation and metabolic activity increase.

12. How many prolotherapy or ozone sessions will I need?

Many patients notice improvement within 1–3 sessions. Deeper ligament or tendon injuries and long-standing degenerative changes may require 3–6 or more treatments, depending on severity, inflammation, and individual healing capacity.

13. Do you use steroids or dextrose in these injections?

We do not use corticosteroids. For prolotherapy-style treatments, we do use a 25% dextrose solution, which is the traditional and evidence-supported formulation for stimulating ligament and tendon repair. Other injections use natural, non-steroidal solutions selected to support tissue healing, improve circulation, and reduce inflammation — ideal for sensitive patients and those seeking a regenerative, whole-body approach.

14. What conditions respond best to injection therapy?

Injection therapy is commonly used for chronic muscle tension, trigger points, joint pain, tendon and ligament injuries, nerve irritation, postural strain, sports injuries, and pain that has not fully resolved with manual therapy alone. It is especially effective when structural or neuromuscular dysfunction is contributing to symptoms.

15. Can injection therapy help chronic pain that hasn’t responded to other treatments?

Yes. Injection therapy is often used when pain persists despite physical therapy, chiropractic care, massage, or acupuncture alone. By directly addressing dysfunctional tissue, injections can help break long-standing pain cycles and restore normal movement patterns.

16. Is injection therapy appropriate for sensitive patients?

Yes. Solutions, volumes, and techniques are adjusted for sensitivity. We prioritize gentle application, precise targeting, and integration with nervous system regulation to minimize reactivity and support tolerance.

17. How quickly will I notice results after an injection?

Some patients notice improvement within hours to days, particularly with trigger point injections. Regenerative therapies such as prolotherapy or ozone support healing over time, with continued improvement between sessions as tissue repair progresses.

18. What is the downtime after injection therapy?

Downtime varies depending on the type of injection used.

For trigger point or non-regenerative injections, downtime is typically minimal. Most patients resume normal daily activities the same day or the following day. Temporary soreness or stiffness is common and usually resolves within 24–72 hours.

For prolotherapy or regenerative-style injections, a short period of relative rest is recommended to allow proper tissue repair. Patients are typically advised to avoid strenuous activity and heavy exercise for 3–7 days, depending on the area treated and individual healing response. Normal daily activities are usually permitted, and gradual return to exercise is guided as healing progresses.

Clear post-treatment instructions are provided to support optimal recovery and results.

19. Can injection therapy reduce the need for pain medications?

In many cases, yes. By addressing underlying tissue dysfunction and promoting healing, injection therapy may reduce reliance on pain medications over time. Any medication changes are coordinated appropriately and safely.

20. How do you decide which type of injection is best for me?

Injection selection is based on a comprehensive assessment of biomechanics, tissue quality, pain patterns, imaging when available, activity level, and treatment goals. The goal is always to choose the least invasive option that provides meaningful, lasting improvement.

21. Why should anti-inflammatory medications be avoided with prolotherapy?

Prolotherapy works by intentionally stimulating a mild, controlled inflammatory response that signals the body to repair and strengthen ligaments and tendons. Anti-inflammatory medications—such as NSAIDs—can interfere with this healing process by suppressing the very inflammatory signals needed for tissue regeneration.

For this reason, patients are typically advised to avoid anti-inflammatory medications before and after prolotherapy treatments for a specified period. Alternative pain management strategies may be recommended to support comfort without disrupting the regenerative response.

Specific guidance is provided based on the injection type, treatment area, and individual medical considerations.

22. Should I avoid icing after prolotherapy injections?

Yes. Icing is generally discouraged after prolotherapy because it suppresses the inflammatory response required for tissue repair. Prolotherapy relies on a controlled healing response to stimulate collagen regeneration in ligaments and tendons. Suppressing this response may reduce effectiveness. Post-treatment guidance is provided based on the injection type and area treated.

23. How does prolotherapy differ from PRP or stem cell injections?

Prolotherapy uses a dextrose-based solution to stimulate the body’s natural repair response and strengthen connective tissue. PRP and stem cell therapies involve biologic materials derived from blood or tissue. Prolotherapy is less invasive, does not require blood draws or processing, and is often an effective first-line regenerative option for instability-related pain.

24. Can prolotherapy help joint instability rather than just pain?

Yes. Prolotherapy is specifically designed to improve ligament and tendon strength, which enhances joint stability. In many cases, pain reduction occurs because stability is restored rather than because pain signals are suppressed.